In the late 18th century, two newlyweds move into the stately mansion of husband Charles Fengriffen. The bride, Catherine, falls victim to a curse placed by a wronged servant on the Fengriffen family and all its descendants.
Locals in an Italian village believe evil has taken over the estate of a recently deceased pianist where murder has taken place. The alleged killer: the pianist's severed hand.
Jon Lansdale is a comic book artist who loses his right hand in a car accident. The hand was not found at the scene of the accident, but it soon returns by itself to follow Jon around, and murder those who anger him.